Laboratory Assays for Epstein-Barr Virus-Related Disease
نویسندگان
چکیده
منابع مشابه
Immunotherapy for Epstein-Barr Virus-Related Lymphomas
Latent EBV infection is associated with several malignancies, including EBV post-transplant lymphoproliferative disorders (LPD), Hodgkin and non-Hodgkin lymphomas, nasopharyngeal carcinoma and Burkitt lymphoma. The range of expression of latent EBV antigens varies in these tumors, which influences how susceptible the tumors are to immunotherapeutic approaches. Tumors expressing type III latency...
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In 1958, Denis Burkitt described B cell lymphomas in 2to 14-year-old African children from malaria-endemic areas.1 In 1964, Michael Anthony Epstein and Yvonne Barr found that immortalized B lymphocyte cell lines derived from these tumors spontaneously released a herpesvirus.2 Thus, Epstein-Barr virus (EBV) was discovered by examining electron micrographs of cells cultured from Burkitt’s lymphom...
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Epstein-Barr virus (EBV) was the first recognized human tumor virus, but it is not the causative agent for the tumor in which it was discovered, Burkitt lymphoma. Common to all Burkitt lymphomas, endemic or sporadic, are distinctive chromosomal translocations that reactivate expression of the c-myc protooncogene and comprise the primary oncogenic mechanism. EBV is at least a contributory cofact...
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Hodgkin's disease is an unusual cancer because the malignant cells constitute only a minority of the total tumour mass and, as a consequence, the study of these cells has been a major challenge. Recently, the application of newer technologies, such as single cell polymerase chain reaction (PCR) and gene expression array analysis, to the study of Hodgkin's disease have yielded new insights into ...
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ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2008
ISSN: 1525-1578
DOI: 10.2353/jmoldx.2008.080023